The Effect of Aspirin on Lung Mucociliary Clearance
- 20 January 1983
- journal article
- clinical trial
- Published by Massachusetts Medical Society in New England Journal of Medicine
- Vol. 308 (3), 139-141
- https://doi.org/10.1056/nejm198301203080306
Abstract
THE removal of inhaled particles, bacteria, and cellular debris by mucociliary clearance has an important role in the maintenance of healthy lungs. Particles are carried on mucus that is transported cephalad on the tips of beating cilia that are immersed in a layer of serous fluid.1 When the mucus reaches the pharynx it is swallowed along with the transported particles.The efficiency of mucus transport in individual airways and whole-lung mucociliary clearance has been investigated in health and disease and in response to various drugs and toxic agents.2 3 4 5 6 7 8 9 10 11 12 13 In vitro studies in animals have demonstrated an increase in the rate . . .Keywords
This publication has 11 references indexed in Scilit:
- Coordination of mucociliary transport in human trachea and intrapulmonary airwaysJournal of Applied Physiology, 1981
- Effects of sulfuric acid aerosol on respiratory mechanics and mucociliary particle clearance in healthy nonsmoking adultsAihaj Journal, 1981
- Lung Mucociliary Clearance in Normal Subjects during Selective and Non-Selective β-Adrenoreceptor BlockadeClinical Science, 1980
- Increased Mucociliary Transport by Cholinergic StimulationArchives of environmental health, 1974
- Results of an analytical model of mucociliary pumping.Journal of Applied Physiology, 1974
- Patterns of Distribution and Clearance of Aerosols in Patients with Bronchiectasis1,2American Review of Respiratory Disease, 1972
- An Organ Culture Study of the Effect of Drugs on the Secretory Activity of the Human Bronchial Submucosal GlandClinical Science, 1972
- Deposition and clearance of 2 μ particles in the tracheobronchial tree of normal subjects—smokers and nonsmokersJCI Insight, 1971
- Inhibition of Prostaglandin Synthesis as a Mechanism of Action for Aspirin-like DrugsNature New Biology, 1971
- The Characteristics of Bronchial Clearance in Humans and the Effects of Cigarette SmokingArchives of environmental health, 1969