Failure to secrete immunoreactive insulin by rats fed a low protein diet
- 1 February 1983
- journal article
- research article
- Published by Oxford University Press (OUP) in Acta Endocrinologica
- Vol. 102 (2), 240-245
- https://doi.org/10.1530/acta.0.1020240
Abstract
Rats fed a 6% protein diet for 14 wk showed a normal glucose tolerance but failed to release immunoreactive insulin (IRI), following i.v. glucose. The isolated perfused pancreas of the rats fed the 6% protein diet secreted 11 times less IRI than the isolated pancreas prepared from the rats reared on an 18% protein diet when both were subjected to the same glucose challenge. This difference occurred despite the fact that the total IRI content of the pancreas'' was not significantly different between the 2 groups. In the protein-malnourished rats it is suggested that the normal glucose tolerance response, despite the failure to release a concommitant amount of IRI, may indicate increased sensitivity to IRI or may be due to the secretion in these animals of a biologically active insulin, which shows no immunological cross-reactivity with pancreatic insulin. Alternately there may be increased peripheral glucose utilization in the low protein rats.This publication has 9 references indexed in Scilit:
- Decreased Insulin Secretion by Isolated Pancreatic Islets from Rats Fed 4% Protein DietExperimental Biology and Medicine, 1980
- PANCREATIC-ISLETS OF MALNOURISHED RATS - QUANTITATIVE HISTOLOGIC AND ELECTRON-MICROSCOPIC FINDINGS1977
- Decreased Plasma Insulin but Normal Glucagon in Rats Fed Low Protein DietsJournal of Nutrition, 1976
- Glucose Tolerance and Insulin Release in Malnourished RatsClinical Science, 1976
- Effect of different levels of protein in “sucrose” and “starch” diets on the glucose tolerance and growthMetabolism, 1966
- Effects of Severe Protein-Calorie Deficiency on the Endocrine Control of Carbohydrate MetabolismDiabetes, 1966
- Effect of dietary sucrose and starch on oral glucose tolerance and insulin-like activityAmerican Journal of Physiology-Legacy Content, 1964
- IMMUNOASSAY OF ENDOGENOUS PLASMA INSULIN IN MANJCI Insight, 1960
- ON THE INTRAVENOUS GLUCOSE TOLERANCE TESTActa Endocrinologica, 1957