Structural studies on protein products of murine chromosome 17: partial amino acid sequence of an H-2Kb molecule.
- 1 October 1976
- journal article
- research article
- Published by Proceedings of the National Academy of Sciences in Proceedings of the National Academy of Sciences of the United States of America
- Vol. 73 (10), 3661-3665
- https://doi.org/10.1073/pnas.73.10.3661
Abstract
By use of single internal radiolabels, 17 of the NH2-terminal 27 amino acids of the murine H-2Kb [histocompatibility-2] molecule were assigned. When the amino acid sequence is compared to that of the murine H-2Kk molecule, there is a minimum of 6 amino acid differences in 19 positions. This high degree of structural diversity confirms, at the level of amino acid sequence, the known polymorphism of the murine H-2 complex. Significant primary structural homology is evident when the murine H-2Kk and H-2Kb sequences are compared to the recently reported partial amino acid sequences of human transplantation antigens. There is modest homology with .beta.2-microglobulin and immunoglobulins, but the available sequence information is insufficient for a satisfactory evaluation of its significance.Keywords
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