Formulation and Evaluation of PLA and PLGA In Situ Implants Containing Secnidazole and/or Doxycycline for Treatment of Periodontitis
Open Access
- 25 July 2008
- journal article
- research article
- Published by Springer Science and Business Media LLC in AAPS PharmSciTech
- Vol. 9 (3), 878-884
- https://doi.org/10.1208/s12249-008-9126-9
Abstract
The purpose of this study is to formulate in situ implants containing doxycycline hydrochloride and/or secnidazole that could be used in the treatment of periodontitis by direct periodontal intrapocket administration. Biodegradable polymers [poly (lactide) (PLA) and poly (lactide-co-glycolide) (PLGA)], each polymer in two concentrations 25%w/w, 35%w/w were used to formulate the in situ implants. The rheological behavior, in vitro drug release and the antimicrobial activity of the prepared implants were evaluated. Increasing the concentration of each polymer increases the viscosity and decreases the percent of the drugs released after 24 h. PLA implants showed a slower drugs release rate than PLGA implants in which the implants composed of 25% PLGA showed the fastest drugs release. The in vitro drug release and antimicrobial activity results were compared with results of Atridox®. Results revealed that the pharmaceutical formulation based on 25% PLGA containing secnidazole and doxycycline hydrochloride has promising activity in treating periodontitis in comparison with Atridox®.Keywords
This publication has 31 references indexed in Scilit:
- Antimicrobial profiles of periodontal pathogens isolated from periodontitis patients in the Netherlands and SpainJournal of Clinical Periodontology, 2005
- Metronidazole concentrations in plasma, saliva and periodontal pockets in patients with periodontitisJournal of Clinical Periodontology, 2005
- Drug release from injectable depots: two different in vitro mechanismsJournal of Controlled Release, 2004
- Effect of chitosan on a periodontal pathogen Porphyromonas gingivalisInternational Journal of Pharmaceutics, 2002
- Controlled Local Delivery of Tetracycline With Polymer Strips in the Treatment of PeriodontitisThe Journal of Periodontology, 2002
- The Thrombocytopenic PurpurasDrugs, 1996
- SecnidazoleDrugs, 1996
- Cellular source, activation and inhibition of dental plaque collagenaseJournal of Clinical Periodontology, 1995
- Antimicrobial strategies for treatment of periodontal diseasesPeriodontology 2000, 1994
- Evaluation of Biodegradable Poly(lactide) Pellets Prepared by Direct CompressionJournal of Pharmaceutical Sciences, 1989