Effect of Whole Body Vibration on Skin Blood Flow and Nitric Oxide Production
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Open Access
- 21 May 2014
- journal article
- research article
- Published by SAGE Publications in Journal of Diabetes Science and Technology
- Vol. 8 (4), 889-894
- https://doi.org/10.1177/1932296814536289
Abstract
Background: : Vascular dysfunction due to hyperglycemia in individuals with diabetes is a factor contributing to distal symmetric polyneuropathy (DSPN). Reactive oxygen species reduce the bioavailability of nitric oxide (NO), a powerful vasodilator, resulting in reduced circulation and nerve ischemia. Increases in blood NO concentrations and circulation have been attributed to whole body vibration (WBV). The purpose of this study was to the determine the effects of low-frequency, low-amplitude WBV on whole blood NO concentrations and skin blood flow (SBF) in individuals with symptoms of DSPN. Methods: : Ten patients with diabetes and impaired sensory perception in the lower limbs participated in this crossover study. Each submitted to 2 treatment conditions, WBV and sham, with a 1-week washout period between. Blood draws for NO analysis and laser Doppler imager scans of SBF were performed before, immediately after, and following a 5-minute recovery of each of the treatments. Results: : Low-frequency, low-amplitude WBV significantly increased SBF compared to the sham condition (F2,18 = 5.82, P = .0115). Whole blood NO concentrations did not differ between the WBV and sham conditions immediately or 5 minutes after treatment (F2,18 = 1.88, P = .1813). Conclusions: : These findings demonstrate that patients with diabetes respond to WBV with increased SBF compared to the sham condition. The implication is that WBV is a potential nonpharmacological therapy for neurovascular complications of diabetes.Keywords
This publication has 29 references indexed in Scilit:
- Comparison between laser speckle contrast imaging and laser Doppler imaging to assess skin blood flow in humansMicrovascular Research, 2011
- Shear stress activation of nitric oxide synthase and increased nitric oxide levels in human red blood cellsNitric Oxide, 2011
- Whole‐body vibration dosage alters leg blood flowClinical Physiology and Functional Imaging, 2008
- On the Cardiovascular Effects of Whole‐Body Vibration Part I. Longitudinal Effects: Hydrodynamic AnalysisStudies in Applied Mathematics, 2007
- Vibration training: benefits and risksJournal of Biomechanics, 2006
- Neurovascular disease, antioxidants and glycation in diabetesDiabetes/Metabolism Research and Reviews, 2002
- Biochemistry and molecular cell biology of diabetic complicationsNature, 2001
- The relationship of vascular changes to metabolic factors in diabetes mellitus and their role in the development of peripheral nerve complicationsDiabetes/Metabolism Research and Reviews, 1994
- Skin Blood Flow and Current Perception in Pentoxifylline-Treated Diabetic NeuropathyAngiology, 1992
- A laser Doppler scanner for imaging blood flow in skinJournal of Biomedical Engineering, 1991