THE INFLUENCE OF HISTAMINE ON EPITHELIAL CELL PROLIFERATION IN THE JEJUNUM OF THE RAT
- 1 August 1976
- journal article
- Published by Wiley in Clinical and Experimental Pharmacology and Physiology
- Vol. 3 (4), 369-373
- https://doi.org/10.1111/j.1440-1681.1976.tb00613.x
Abstract
1. The influence of histamine and histamine receptor blockade on the mitotic rate in epithelial cell proliferation in epithelial cells lining the crypts of Lieberkühn in rat jejunum was studied. 2. Histamine injection resulted in an increase in the mitotic rate. This increase in mitotic rate was blocked by metiamide but not by mepyramine. 3. Prevention of histamine synthesis by α-methylhistidine administration did not alter the mitotic rate. 4. The mechanism by which histamine may influence crypt cell proliferation and and possible role of cyclic GMP in this mediation are discussed.Keywords
This publication has 12 references indexed in Scilit:
- The influence of cholinoceptor activity on the mitotic rate in the crypts of Lieberkühn in rat jejunumClinical and Experimental Pharmacology and Physiology, 1975
- Decreased Mitotic Activity in the Stomach, Duodenum and Colon of Rats Treated with High Doses of HistaminePharmacology, 1975
- Variations in crypt cell cycle time and mitotic time in the small intestine of the ratVirchows Archiv B Cell Pathology, 1973
- Proliferation of epithelial cells in the jejunal crypts of adrenalectomized and adrenocortical hormone treated ratsVirchows Archiv B Cell Pathology, 1973
- Histamine H1 and H2-Receptors at a Ganglionic SynapseNature, 1973
- Guanosine 3′:5′-Cyclic Monophosphate: A Possible Intracellular Mediator of Mitogenic Influences in LymphocytesProceedings of the National Academy of Sciences of the United States of America, 1972
- Epithelial-Cell Renewal in Cultured Duodenal Biopsies in Celiac SprueNew England Journal of Medicine, 1970
- Observations on the inhibition of histamine formationThe Journal of Physiology, 1963
- Effect of Serotonin upon Liver Cells of Young Rats.Experimental Biology and Medicine, 1959
- A STUDY OF THE ADRENOTROPIC RECEPTORSAmerican Journal of Physiology-Legacy Content, 1948