Faculty Opinions recommendation of Immunologic self-tolerance maintained by activated T cells expressing IL-2 receptor alpha-chains (CD25). Breakdown of a single mechanism of self-tolerance causes various autoimmune diseases.

Abstract

This excellent study identified CD25, the high-affinity interleukin-2 receptor α chain, as an accurate marker for suppressor T cells. This Recommendation is of an article referenced in an F1000 Faculty Review also written by David L. Owen and Michael A. Farrar.