Surface modification of polymeric biomaterials with poly(ethylene oxide), albumin, and heparin for reduced thrombogenicity
- 1 January 1993
- journal article
- review article
- Published by Informa UK Limited in Journal of Biomaterials Science, Polymer Edition
- Vol. 4 (3), 217-234
- https://doi.org/10.1163/156856293x00537
Abstract
Appropriate surface modification has significantly improved the blood compatibility of polymeric biomaterials. This article reviews methods of surface modification with water-soluble polymers, such as polyethylene oxide (PEO), albumin, and heparin. PEO is a synthetic, neutral, watersoluble polymer, while albumin and heparin are a natural globular protein and an anionic polysaccharide, respectively. When grafted onto the surface, all three macromolecules share a common feature to reduce thrombogenicity of biomaterials. The reduced thrombogenicity is due to the unique hydrodynamic properties of the grafted macromolecules. In aqueous medium, surface-bound water-soluble polymers are expected to be highly flexible and extend into the bulk solution. Biomaterials grafted with either PEO, albumin, or heparin are able to resist plasma porotein adsorption and platelet adhesion predominantly by a steric repulsion mechanism.Keywords
This publication has 78 references indexed in Scilit:
- Platelet deposition studies on copolyether urethanes modified with poly(ethylene oxide)Biomaterials, 1990
- In vitro platelet interactions with a heparin–polyvinyl alcohol hydrogelJournal of Biomedical Materials Research, 1989
- Effect of heparin–pva hydrogel on platelets in a chronic canine arterio‐venous shuntJournal of Biomedical Materials Research, 1989
- Poly(dimethylsiloxane)‐poly(ethyleneoxide)‐heparin block copolymers. I. Synthesis and characterizationJournal of Biomedical Materials Research, 1988
- The Search for Thromboresistance Using Immobilized HeparinAnnals of the New York Academy of Sciences, 1987
- Hydrated Dynamic SurfacesASAIO Journal, 1987
- Heparinizable materials (III). Heparin retention power of a poly(amido-amine) either as crosslinked resin, or surface-grafted on PVCBiomaterials, 1984
- Influence of adsorbed proteins on the stability of polystyrene latex particlesFaraday Discussions of the Chemical Society, 1978
- Complete amino acid sequence of human serum albuminFEBS Letters, 1975
- Heparin Bonding on Colloidal Graphite SurfacesScience, 1963