Ultrastructural study of 28 cases of Ewing's sarcoma: Typical and atypical forms
- 1 April 1978
- Vol. 41 (4), 1362-1373
- https://doi.org/10.1002/1097-0142(197804)41:4<1362::aid-cncr2820410421>3.0.co;2-f
Abstract
The characteristics of 35 round cell sarcomas of bones are analyzed by optical and electron microscopical means, 28 cases of Ewing's sarcoma and 7 cases of malignant lymphomas (reticulum cell sarcoma) being distinguished. The existence of a morphological diversity within the Ewing's sarcoma group allows the authors to differentiate a conventional form of Ewing's sarcoma (21 cases) consisting of principal blastemic cells and secondary degenerative ones (dark cells) from an atypical variant (7 cases of atypical Ewin's sarcoma) whose structure adopts either an immature mesenchymal or histiocytic appearance. The ultrastructure of the atypical Ewing's cells demonstrates variability in size and in the nucleus, which is grooved and possesses prominent nucleoli. In the cytoplasm, in addition to the existence of a variable amount of glycogen, more highly differentiated structures appear when a comparison is made with the principal cells of the conventional Ewing's sarcoma. There exist filaments and mitochondria complexes, desmosomic-like junctions and profiles of endo-plasmic reticulum. No transitional forms between the conventional and the atypical variants of Ewing's sarcoma have been observed. According to this analysis, when compared to other bone malignancies, the presence of glycogen as a means for identifying Ewing's sarcoma seems to be of restricted value. No clinical or anatomical differences could be established between either variant of Ewing's sarcoma.This publication has 25 references indexed in Scilit:
- Ultrastructural study of an odontogenic myxomaOral Surgery, Oral Medicine, Oral Pathology, 1976
- Cytologic and Cytochemical Behavior of Primary Malignant Bone TumorsPublished by Springer Science and Business Media LLC ,1976
- Primary malignant fibrous histiocytoma of boneCancer, 1975
- The Application of Electron Microscopy to the Diagnostic Differentiation of Ewing??s Sarcoma and Reticulum Cell Sarcoma of BonePublished by Ovid Technologies (Wolters Kluwer Health) ,1973
- Ultrastructural studies on the acute leukemic myeloblastBlut: Zeitschrift für die Gesamte Blutforschung, 1972
- Distribution of glycogen in osteoblasts of the fetal ratJournal of Ultrastructure Research, 1971
- Cytochemical Studies of Acute LeukemiasActa Haematologica, 1970
- The curability of Ewing's endothelioma of bone in childrenThe Journal of Pediatrics, 1967
- A SIMPLIFIED LEAD CITRATE STAIN FOR USE IN ELECTRON MICROSCOPYThe Journal of cell biology, 1965
- Araldite as an Embedding Medium for Electron MicroscopyThe Journal of cell biology, 1958