Structural and immunological similarities between simian sarcoma virus gene product(s) and human platelet-derived growth factor
- 1 October 1983
- journal article
- research article
- Published by Springer Science and Business Media LLC in Nature
- Vol. 305 (5935), 605-608
- https://doi.org/10.1038/305605a0
Abstract
The predicted amino acid sequence of the simian sarcoma virus (SSV) transforming gene product, p28SIS, closely corresponds to that of human platelet-derived growth factor (PDGF). We demonstrate that p28SIS rapidly undergoes a series of discrete processing steps including dimer formation and proteolytic digestion to yield molecules structurally and immunologically resembling biologically active PDGF.This publication has 28 references indexed in Scilit:
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