Left ventricular and carotid structure in untreated, uncomplicated essential hypertension: results from the Assessment Prognostic Risk Observational Survey (APROS)
- 29 July 2004
- journal article
- research article
- Published by Springer Science and Business Media LLC in Journal of Human Hypertension
- Vol. 18 (12), 891-896
- https://doi.org/10.1038/sj.jhh.1001759
Abstract
The impact of hypertension on left ventricular (LV) and vascular structure and the relation of left ventricular hypertrophy (LVH) with vascular changes in untreated essential hypertensives has not been fully explored. This study investigated the prevalence of structural abnormalities of LV and carotid arteries and their determinants in a large population of untreated, uncomplicated essential hypertensive patients. The Assessment of Prognostic Risk Observational Survey was a multicentre (44 centres) prospective study including 1142 untreated hypertensives classified as low or medium cardiovascular risk on the basis of the routine diagnostic work-up recommended by the 1999 World Health Organization/International Society of Hypertension guidelines. All patients underwent ultrasound examinations of the heart and carotid arteries. LVH and carotid structural changes were diagnosed when: (1) LV mass index exceeded 125 g/m2 in men and 110 g/m2 in women; (2) there was at least one plaque (focal thickening>1.3 mm) in any segment of either carotid artery or a diffuse common carotid intima–media thickness (IMT) (average of IMT0.8 mm) was present. Overall, 1074 patients (504 women, mean age 48.1±11.4 years) completed the study with ultrasonographic examinations of good technical quality. The prevalences of LVH and LV concentric remodelling in the total population were 26.8 and 10.7%, respectively. Eccentric hypertrophy was more prevalent than concentric hypertrophy (15.2 vs 11.6%). One or more carotid plaques or thickening were present in 27.4% of the patients. A stepwise increase in IM thickness occurred from the lowest values in patients with normal cardiac mass and geometry (0.68 mm) to intermediate in those with LV remodelling (0.76 mm) and eccentric LVH (0.81 mm) and to the highest level in patients with concentric LVH (0.87 mm). Patients with LV concentric remodelling and concentric LVH had a significantly greater relative carotid wall thickness than those with normal geometry and eccentric LVH (0.25 and 0.26 vs 0.18 and 0.19, respectively, P<0.01). According to a multivariate analysis age, blood glucose, systolic BP and pulse pressure were the main independent predictors of LVH, while age, systolic BP and total cholesterol were the variables with the greatest impact on IM thickening. To conclude, this study shows that: (1) altered patterns of LV structure and geometry and carotid structural changes occur in a large fraction of patients with untreated essential hypertension; (2) there is a significant association between carotid wall thickening and LVH; (3) the probability of LVH or carotid thickening is significantly greater in elderly, in patients with higher systolic BP and in patients with associated metabolic risk factors.Keywords
This publication has 21 references indexed in Scilit:
- Calcium Antagonist Lacidipine Slows Down Progression of Asymptomatic Carotid AtherosclerosisCirculation, 2002
- Prevalence of Left Ventricular Hypertrophy in Hypertensive Patients Without and With Blood Pressure ControlHypertension, 2002
- The Relationship Between Lipids/Lipoproteins and Atherosclerosis in African Americans and WhitesAnnals of Epidemiology, 1999
- 1999 World Health Organization-International Society of Hypertension Guidelines for the Management of HypertensionJournal Of Hypertension, 1999
- Risk factors associated with alterations in carotid intima—media thickness in hypertensionJournal Of Hypertension, 1998
- Hyperinsulinemia and Left Ventricular Geometry in a Work-Site Population in JapanHypertension, 1996
- Patterns of left ventricular hypertrophy and geometric remodeling in essential hypertensionJournal of the American College of Cardiology, 1992
- Early 24-hour blood pressure elevation in normotensive subjects with parental hypertension.Hypertension, 1990
- Prognostic Implications of Echocardiographically Determined Left Ventricular Mass in the Framingham Heart StudyNew England Journal of Medicine, 1990
- Echocardiographic determination of left ventricular mass in man. Anatomic validation of the method.Cell Metabolism, 1977