Recent Advances in the Studies on Luotonins
Open Access
- 13 June 2011
- Vol. 16 (6), 4861-4883
- https://doi.org/10.3390/molecules16064861
Abstract
Luotonins are alkaloids from the aerial parts of Peganum nigellastrum Bunge. that display three major skeleton types. Luotonins A, B, and E are pyrroloquinazolino-quinoline alkaloids, luotonins C and D are canthin-6-one alkaloids, and luotonin F is a 4(3H)-quinazolinone alkaloid. All six luotonins have shown promising cytotoxicities towards selected human cancer cell lines, especially against leukemia P-388 cells. Luotonin A is the most active one, with its activity stemming from topoisomerase I-dependent DNA-cleavage. Such intriguing biological activities and unique structures have led not only to the development of synthetic methods for the efficient synthesis of these compounds, but also to interest in structural modifications for improving the biological properties. Recent progress in the study of luotonins is covered.Keywords
This publication has 57 references indexed in Scilit:
- Two-Step Total Syntheses of Canthin-6-one Alkaloids: New One-Pot Sequential Pd-Catalyzed Suzuki−Miyaura Coupling and Cu-Catalyzed Amidation ReactionOrganic Letters, 2010
- DNA Topoisomerase I Inhibitors: Chemistry, Biology, and Interfacial InhibitionChemical Reviews, 2009
- Synthesis and Biological Properties of Luotonin A DerivativesBulletin of the Korean Chemical Society, 2008
- Unprecedented Aromatic Homolytic Substitutions and Cyclization of Amide-Iminyl Radicals: Experimental and Theoretical StudyChemistry – A European Journal, 2008
- Total synthesis of luotonin A and 14-substituted analoguesOrganic & Biomolecular Chemistry, 2007
- Synthesis and Properties of Luotonin A Homologues and Their Aza-analoguesHETEROCYCLES, 2006
- Extraction, Hemisynthesis, and Synthesis of Canthin-6-one Analogues. Evaluation of Their Antifungal ActivitiesJournal of Natural Products, 2005
- Biogenetic Synthesis of Luotonin FSynthesis, 2002
- Two New Quinazoline-Quinoline Alkaloids from Peganum nigellastrumHETEROCYCLES, 1999
- Plant Antitumor Agents. I. The Isolation and Structure of Camptothecin, a Novel Alkaloidal Leukemia and Tumor Inhibitor from Camptotheca acuminata1,2Journal of the American Chemical Society, 1966