Exercise training reduces myocardial lipid peroxidation following short-term ischemia-reperfusion

Abstract

Exercise training reduces myocardial lipid peroxidation following short-term ischemia-reperfusion.Med. Sci. Sports Exerc., Vol. 30, No. 8, pp. 1211-1216, 1998. The purpose of these experiments was to test the hypothesis that endurance exercise training will reduce myocardial lipid peroxidation following short-term ischemia and reperfusion(I-R). Female Sprague-Dawley rats (4 months old) were randomly assigned to either a sedentary control group (N = 13) or to an exercise training group (N = 13). The exercise trained animals ran 4 d·wk−1 (90 min·d−1) at ∼75% of V˙O2max. Following a 10-wk training program, animals were anesthetized, mechanically ventilated, and the chest was opened by thoracotomy. Coronary occlusion was achieved by a ligature around the left coronary artery; occlusion was maintained for 5 min followed by a 10-min period of reperfusion. Although training did not alter (P > 0.05) myocardial activities of antioxidant enzymes (superoxide dismutase and glutathione peroxidase), training was associated with significant increases (P P These data support the hypothesis that exercise training provides protection against myocardial lipid peroxidation induced by short-term I-R in vivo.