A method to potentiate enteral absorption of interferon and selective delivery into lymphatics.

Abstract

The potentiated absorption of human fibroblast interferon (HuIFN-β) with the aid of lipid-surfactant mixed micelles from the rat large intestine and lymphatic delivery were studied. The administration of HuIFN-β with saline solution alone into the lumen of the large intestine indicated no detectable HuIFN-β in the serum or the lymph for 5 h. Neither lipid (linoleic acid) nor surfactant (HCO60, polyoxyethylene hardened castor oil derivative) could promote the absorption of HuIFN-β. However, the administration with linoleic acid-HCO60 mixed micelles enabled the great absorption of HuIFN-β from the large intestine, and HuIFN-β was delivered into the lymphacics with an extremely high selectivity