A Diastereoselective Synthesis of 2,4-Disubstituted Piperidines: Scaffolds for Drug Discovery
Top Cited Papers
- 21 October 2000
- journal article
- letter
- Published by American Chemical Society (ACS) in Organic Letters
- Vol. 2 (23), 3679-3681
- https://doi.org/10.1021/ol006589o
Abstract
A method for the diastereoselective synthesis of 2,4-disubstituted piperidines has been developed which enables the complete control of reaction selectivity merely by changing the order of the reaction sequence. These targets provide convenient platforms for drug discovery which contain easily modified points of diversity.Keywords
This publication has 5 references indexed in Scilit:
- Second Generation Antimigraine S-Ht1BID Agonists: Structure Activity Relationship and Preclinical Pharmacological DistinctionsCurrent Medicinal Chemistry, 1997
- Plasma concentrations of excitatory amino acids, serine, glycine, taurine and histidine in major depressionEuropean Neuropsychopharmacology, 1995
- Pyridine-derived triflating reagents: An improved preparation of vinyl triflates from metallo enolates.Tetrahedron Letters, 1992
- Asymmetric tandem Mannich-Michael reactions of amino acid ester imines with Danishefsky's dieneThe Journal of Organic Chemistry, 1992
- Surface‐active CompoundsAngewandte Chemie-International Edition, 1966