Asymmetric Reduction of Prochiral Ketones with Chiral Hydride Reagents Prepared from Lithium Aluminium Hydride and (S)-2-(N-Substituted aminomethyl)pyrrolidines
- 1 June 1978
- journal article
- research article
- Published by Oxford University Press (OUP) in Bulletin of the Chemical Society of Japan
- Vol. 51 (6), 1869-1873
- https://doi.org/10.1246/bcsj.51.1869
Abstract
Asymmetric reduction of prochiral ketones with various hydride reagents prepared from lithium aluminium hydride and (S)-2-(N-substituted aminomethyl) pyrrolidines, derived easily by four steps from commercially available (S)-proline, yields optically active alcohols with 13–92% optical purity having the S-configuration.Keywords
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