Glutathione and Nitrosoglutathione in Macrophage Defense againstMycobacterium tuberculosis
Open Access
- 1 March 2005
- journal article
- Published by American Society for Microbiology in Infection and Immunity
- Vol. 73 (3), 1886-1889
- https://doi.org/10.1128/iai.73.3.1886-1889.2005
Abstract
We demonstrate that Mycobacterium tuberculosis grown in vitro is sensitive to glutathione and its derivative S-nitrosoglutathione. Furthermore, our infection studies with J774.1 macrophages indicate that glutathione is essential for the control of the intracellular growth of M. tuberculosis. This study indicates the important role of glutathione in the control of macrophages by M. tuberculosis.Keywords
This publication has 17 references indexed in Scilit:
- Role of Glutathione in Macrophage Control of MycobacteriaInfection and Immunity, 2003
- Toxicity of nitrogen oxides and related oxidants on mycobacteria: M. tuberculosis is resistant to peroxynitrite anionTubercle and Lung Disease, 1999
- Induction of Nitric Oxide in Human Monocytes and Monocyte Cell Lines byMycobacterium tuberculosisNitric Oxide, 1998
- NITRIC OXIDE AND MACROPHAGE FUNCTIONAnnual Review of Immunology, 1997
- Comparison of the roles of reactive oxygen and nitrogen intermediates in the host response to Mycobacterium tuberculosis using transgenic miceTubercle and Lung Disease, 1997
- Tumor necrosis factor-α is required in the protective immune response against mycobacterium tuberculosis in miceImmunity, 1995
- An essential role for interferon gamma in resistance to Mycobacterium tuberculosis infection.The Journal of Experimental Medicine, 1993
- Tuberculosis: Commentary on a Reemergent KillerScience, 1992
- Killing of virulent Mycobacterium tuberculosis by reactive nitrogen intermediates produced by activated murine macrophages.The Journal of Experimental Medicine, 1992
- Glutathione: Is it an evolutionary vestige of the penicillins?Medical Hypotheses, 1987