Effects of Spray Drying on Physicochemical Properties of Chitosan Acid Salts
Open Access
- 11 May 2011
- journal article
- research article
- Published by Springer Science and Business Media LLC in AAPS PharmSciTech
- Vol. 12 (2), 637-649
- https://doi.org/10.1208/s12249-011-9620-3
Abstract
The effects of spray-drying process and acidic solvent system on physicochemical properties of chitosan salts were investigated. Chitosan used in spray dryings was obtained by deacetylation of chitin from lobster (Panulirus argus) origin. The chitosan acid salts were prepared in a laboratory-scale spray drier, and organic acetic acid, lactic acid, and citric acid were used as solvents in the process. The physicochemical properties of chitosan salts were investigated by means of solid-state CP-MAS 13C nuclear magnetic resonance (NMR), X-ray powder diffraction (XRPD), differential scanning calorimetry, and Fourier transform infrared spectrometry (FTIR) and near-infrared spectroscopy. The morphology of spray-dried chitosan acid salts showed tendency toward higher sphericity when higher temperatures in a spray-drying process were applied. Analysis by XRPD indicated that all chitosan acid salts studied were amorphous solids. Solid-state 13C NMR spectra revealed the evidence of the partial conversion of chitosan acetate to chitin and also conversion to acetyl amide form which appears to be dependent on the spray-drying process. The FTIR spectra suggested that the organic acids applied in spray drying may interact with chitosan at the position of amino groups to form chitosan salts. With all three chitosan acid salts, the FTIR bands at 1,597 and 1,615 cm−1 were diminished suggesting that –NH groups are protonated. The FTIR spectra of all chitosan acid salts exhibited ammonium and carboxylate bands at 1,630 and 1,556 cm−1, respectively. In conclusion, spray drying is a potential method of preparing acid salts from chitosan obtained by deacetylation of chitin from lobster (P. argus) origin.Keywords
This publication has 37 references indexed in Scilit:
- Novel Chitosan-Spotted Alginate Fibers from Wet-Spinning of Alginate Solutions Containing Emulsified Chitosan−Citrate Complex and their CharacterizationBiomacromolecules, 2008
- Non-viral dried powders for respiratory gene delivery prepared by cationic and chitosan loaded liposomesInternational Journal of Pharmaceutics, 2008
- Characterization of chitosan/citrate and chitosan/acetate films and applications for wound healingJournal of Applied Polymer Science, 2008
- Chitosan-modifications and applications: Opportunities galoreReactive and Functional Polymers, 2008
- Evaluation of chitosan salts as non-viral gene vectors in CHO-K1 cellsInternational Journal of Pharmaceutics, 2008
- Chitosan Ascorbate: A Chitosan Salt with Improved Penetration Enhancement PropertiesPharmaceutical Development and Technology, 2008
- Chitosan lactate as a nonviral gene delivery vector in COS-1 cellsAAPS PharmSciTech, 2006
- Spray Drying of Biopharmaceuticals: Stability and Process ConsiderationsDrying Technology, 2006
- Characterization of chitosan acetate as a binder for sustained release tabletsJournal of Controlled Release, 2004
- A study on cytocompatible poly(chitosan-g-l-lactic acid)Polymer, 2003