Differential regulation of proteasome functionality in reproductive vs. somatic tissues of Drosophila during aging or oxidative stress
Open Access
- 8 March 2013
- journal article
- research article
- Published by Wiley in The FASEB Journal
- Vol. 27 (6), 2407-2420
- https://doi.org/10.1096/fj.12-221408
Abstract
Proteasome is central to proteostasis maintenance, as it degrades both normal and damaged proteins. Herein, we undertook a detailed analysis of proteasome regulation in the in vivo setting of Drosoph...Keywords
This publication has 55 references indexed in Scilit:
- Age-specificity and the evolution of senescence: a discussionBiogerontology, 2012
- Pharmacological targets in the ubiquitin system offer new ways of treating cancer, neurodegenerative disorders and infectious diseasesExpert Reviews in Molecular Medicine, 2011
- The redox stress hypothesis of agingFree Radical Biology & Medicine, 2011
- The immunoproteasome, the 20S proteasome and the PA28αβ proteasome regulator are oxidative-stress-adaptive proteolytic complexesBiochemical Journal, 2010
- Insights into the molecular architecture of the 26S proteasomeProceedings of the National Academy of Sciences, 2009
- Selective benefits of damage partitioning in unicellular systems and its effects on agingProceedings of the National Academy of Sciences, 2008
- Puzzles, promises and a cure for ageingNature, 2008
- Keap1/Nrf2 Signaling Regulates Oxidative Stress Tolerance and Lifespan in DrosophilaDevelopmental Cell, 2008
- Sir2p-dependent protein segregation gives rise to a superior reactive oxygen species management in the progeny of Saccharomyces cerevisiaeProceedings of the National Academy of Sciences of the United States of America, 2007
- Elimination of damaged proteins during differentiation of embryonic stem cellsProceedings of the National Academy of Sciences of the United States of America, 2006