Blockage of axonal transport induced by acute, graded compression of the rabbit vagus nerve.
Open Access
- 1 August 1980
- journal article
- research article
- Published by BMJ in Journal of Neurology, Neurosurgery & Psychiatry
- Vol. 43 (8), 690-698
- https://doi.org/10.1136/jnnp.43.8.690
Abstract
Rapid axonal transport in rabbit vagus nerve was studied during and after graded nerve compression. Proteins of the rapid axonal transport were labelled by micro-injection of 3H-leucine into the nodose ganglion and the cervical vagus nerve was subjected to graded compression by a small "mini-cuff" applied directly to the exposed nerve trunk. The results showed that even slight trauma to the nerve, in this model represented by a pressure at 50 mmHg applied for two hours, may induce accumulation of axonally transported proteins at the level of compression. This transport block was, however, reversible within one day. 200 mmHg and 400 mmHg applied for two hours similarly induced a block of axonal transport persisting up to at least one and three days respectively after the compression. Time for recovery of normal transport was correlated with the magnitude of the pressure applied to the nerve. The results indicate that axons may survive, that is not undergo Wallerian degeneration, after blockage of rapid axonal transport persisting at least one day after the compression trauma.This publication has 36 references indexed in Scilit:
- Effects of pressure on fast axoplasmic flow. An in vitro study in the vagus nerve of rabbitsActa Physiologica Scandinavica, 1978
- Anoxic block and recovery of axoplasmic transport and electrical excitability of nerveJournal of Neurobiology, 1978
- Increased endoneurial fluid pressure in experimental lead neuropathyNature, 1977
- Effects of Chymopapain on Nerve Tissue An Experimental Study on the Structure and Function of Peripheral Nerve Tissue in Rabbits After Local Application of ChymopapainSpine, 1976
- Ionic Requirements for Rapid Axonal Transportin vitroin Frog Sciatic NervesActa Physiologica Scandinavica, 1975
- Recovery of nerve conduction after a pneumatic tourniquet: observations on the hind-limb of the baboonJournal of Neurology, Neurosurgery & Psychiatry, 1972
- Contributions of Axoplasmic Transport to Synaptic Structures and FunctionsInternational Journal of Neuroscience, 1972
- SYNTHESIS, MIGRATION AND TURNOVER OF PROTEIN IN RETINAL GANGLION CELLSJournal of Neurochemistry, 1971
- FAST AND SLOW COMPONENTS IN AXONAL TRANSPORT OF PROTEINThe Journal of cell biology, 1968
- Some Quantitative Studies on the Noradrenaline Content in the Cell Bodies and Terminals of a Sympathetic Adrenergic Neuron SystemActa Physiologica Scandinavica, 1966