Selective and Effective Iodination of Alkyl-substituted Benzenes with Elemental Iodine Activated by SelectfluorTM F-TEDA-BF4

Abstract

Selective direct introduction of an iodine atom into alkyl-substituted benzene derivatives was effectively achieved by reaction of target molecules with elemental iodine in the presence of 1-chloromethyl-4-fluoro-1,4-diazoniabicyclo[2.2.2]octane bis(tetrafluoroborate) (Selectfluor^{Τ Μ} F-TEDA-BF₄). The number of iodine atoms introduced could be modulated by the molar ratio between substrate, iodine and F-TEDA-BF₄.