Enhancing effect of cholecystectomy on colon carcinogenesis induced by methylazoxymethanol acetate in hamsters
- 1 August 1986
- journal article
- Published by Ovid Technologies (Wolters Kluwer Health) in Diseases of the Colon & Rectum
- Vol. 29 (8), 492-494
- https://doi.org/10.1007/bf02562600
Abstract
The effect of cholecystectomy on colon carcinogenesis induced by methylazoxymethanol (MAM) acetate was examined in four groups of Syrian golden hamsters. For the sexes combined, the incidences of total large intestinal neoplasms and adenomas in Group 1, which received cholecystectomy and a single intravenous injection of MAM acetate (20 mg/kg body weight), were significantly higher than those of hamsters in Group 2, which were given MAM acetate alone. The combined multiplicities of total large intestinal neoplasms from male and female hamsters, and the multiplicities of those in females of Group 1 were also significantly higher than those in animals in Group 2, respectively. No intestinal tumors were observed in hamsters in Group 3 (cholecystectomy alone) or Group 4 (untreated control). These results indicate an enhancing effect of cholecystectomy on MAM acetate-induced large intestinal carcinogenesis in hamsters.Keywords
This publication has 16 references indexed in Scilit:
- The possible carcinogenic effect of cholecystectomy. No postoperative increase in the proportion of secondary bile acidsCancer, 1983
- Increased Risk of Colorectal Cancer After CholecystectomyAnnals of Surgery, 1981
- CHOLECYSTECTOMY AND RIGHT-SIDED COLON CANCER: AN EPIDEMIOLOGICAL STUDYThe Lancet, 1981
- CHOLECYSTECTOMY AND CARCINOMA OF THE COLONThe Lancet, 1981
- Cholecystectomy and cancer of the large bowelBritish Journal of Surgery, 1981
- Relationship between cholecystectomy and ascending colon cancerCancer, 1980
- FÆCAL BILE-ACIDS AND CLOSTRIDIA IN PATIENTS WITH CANCER OF THE LARGE BOWELThe Lancet, 1975
- Promoting Effect of Bile Acids on Colon Carcinogenesis After Intrarectal Instillation of N -Methyl- N ′ nitro- N -nitrosoguanidine in Rats 2JNCI Journal of the National Cancer Institute, 1974
- Environmental factors of cancer of the colon and rectumII. Japanese epidemiological dataCancer, 1969
- Environmental factors of cancer of the colon and rectumCancer, 1967