Some Effects of Prolonged Undernutrition on Carbohydrate Metabolism in Rats
- 30 November 1956
- journal article
- research article
- Published by American Physiological Society in American Journal of Physiology-Legacy Content
- Vol. 187 (3), 432-436
- https://doi.org/10.1152/ajplegacy.1956.187.3.432
Abstract
A) Rats fed 10 gm of ground Rockland diet/day for 4–6 weeks and then fasted for 24 hours showed an enhanced insulin sensitivity as compared with ad libitum-fed rats that were fasted for the same length of time. The fasting blood sugar and liver glycogen concentrations were significantly higher in underfed animals. B) Underfed rats were fasted 24 hours, then fed 5 gm/ 100 gm body weight and tested 8 hours later. These rats exhibited a) no greater insulin sensitivity, b) lower blood sugar levels and c) a smaller rise in liver glycogen concentration than similarly treated ad libitum-fed animals. Intestinal absorption of glucose was not diminished in the undernourished rats. C) Cortisone treatment (0.5 mg/100 gm body wt/day for 5 days) abolished the insulin sensitivity of underfed rats without altering the hepatic glycogen concentration. Somatotrophin (0.5 mg Armour standard equivalent/100 gm body wt/day for 5 days) did not improve their insulin tolerance. After functional evisceration, the blood sugar fall (if expressed as percentage of the initial level) was significantly slower in underfed than in ad libitum-fed rats. However, the decline of the blood sugar level appeared to be more markedly enhanced by insulin in the underfed animals.Keywords
This publication has 8 references indexed in Scilit:
- INFLUENCE OF SOMATOTROPHIN AND CORTISONE ON THE INSULIN SENSITIVITY OF RATS12Endocrinology, 1956
- Influence of Previous Diet on Hepatic Glycogenesis and LipogenesisAmerican Journal of Physiology-Legacy Content, 1955
- METABOLIC DEFECTS IN THE LIVER OF FASTED RATS AS SHOWN BY UTILIZATION OF C14-LABELED GLUCOSE AND FRUCTOSEJournal of Biological Chemistry, 1953
- STUDIES ON HYPOGLYCEMIA RESPONSIVENESS1953
- TWO BLOCKS IN CARBOHYDRATE UTILIZATION IN THE LIVER OF THE DIABETIC RATJournal of Biological Chemistry, 1951
- Effect of Phlorhizin on Intestinal Absorption of Glucose, Galactose, Fructose, Mannose, and SorboseExperimental Biology and Medicine, 1950
- Adaptation of Carbohydrate Metabolism to UndernutritionBritish Journal of Nutrition, 1950
- UNDERNUTRITION AND CARBOHYDRATE METABOLISMPhysiological Reviews, 1938