The B-cell antigen receptor of the five immunoglobulin classes
- 1 August 1991
- journal article
- research article
- Published by Springer Science and Business Media LLC in Nature
- Vol. 352 (6338), 777-781
- https://doi.org/10.1038/352777a0
Abstract
Several proteins associate with surface IgM to form the antigen receptor. We show that just two, the α and β associated chains, are sufficient to reconstitute an IgM surface receptor in fibroblasts. Contrary to expectation, α common a chain associ-ates with all five immunoglobulin classes. We pro-pose that B-cell antigen receptors consist of a common α/β heterodimer associated with each immunoglobulin class. But the classes differ both in the glycosylation of their associated α chain and in their dependence on α/β for surface transport.Keywords
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