Vitamin K Deficiency in Rats Induced by the Feeding of Irradiated Beef

Abstract
Consumption of diets containing gamma-ray irradiated (2.79 or 5.58 × 104 rad) beef resulted in internal hemorrhages and prolonged prothrombin times in growing male rats. Generally the female rat did not show this syndrome. The lesion was induced by freshly irradiated beef as well as irradiated beef which has been stored for over 6 months at room temperature. Supplementation with vitamin K prevented the hemorrhagic diathesis in rats consuming irradiated beef.