A Combination of Anti-PD-L1 Treatment and Therapeutic Vaccination Facilitates Improved Retroviral Clearance via Reactivation of Highly Exhausted T Cells
Open Access
- 23 February 2021
- journal article
- research article
- Published by American Society for Microbiology in mBio
- Vol. 12 (1)
- https://doi.org/10.1128/mbio.02121-20
Abstract
Despite significant efforts, vaccines are not yet available for every infectious pathogen, and the search for a protective approach to prevent the establishment of chronic infections, i.e., with HIV, continues. Immune checkpoint therapies targeting inhibitory receptors, such as PD-1, have shown impressive results against solid tumors.Keywords
Funding Information
- Deutsche Forschungsgemeinschaft (RTG1949)
- Deutsche Forschungsgemeinschaft (TRR60)
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