Selectins and Immune Cells in Acute Myocardial Infarction and Post-infarction Ventricular Remodeling: Pathophysiology and Novel Treatments
Open Access
- 27 February 2019
- journal article
- review article
- Published by Frontiers Media SA in Frontiers in Immunology
- Vol. 10, 300
- https://doi.org/10.3389/fimmu.2019.00300
Abstract
The glycosciences aim to understand the impact of extracellular and intracellular carbohydrate structures on biological function. These glycans primarily fall into three major groups: lipid-linked carbohydrates that are referred to as glycosphingolipids or simply glycolipids; relatively short carbohydrate chains that are often O- or N-linked to proteins yielding common glycoproteins; and extended linear polymeric carbohydrate structures that are referred to as glycosaminoglycans (GAGs). Whereas, the impact of such carbohydrate structures has been extensively examined in cancer biology, their role in acute and chronic heart disease is less studied. In this context, a growing body of evidence indicates that glycans play an important role in immune mediated cell recruitment to damaged heart tissue to initiate wound healing and repair after injury. This is particularly important following ischemia and reperfusion that occurs in the heart in the setting of acute myocardial infarction. Here, immune system-mediated repair of the damaged myocardium plays a critical role in determining post-infarction ventricular remodeling, cardiac function, and patient outcome. Further, alterations in immune cell activity can promote the development of heart failure. The present review summarizes our current understanding of the phases of immune-mediated repair following myocardial infarction. It discusses what is known regarding glycans in mediating the recruitment of circulating immune cells during the early inflammatory stage of post-infarction repair, with focus on the selectin family of adhesion molecules. It offers future directions for research aimed at utilizing our knowledge of mechanisms underlying immune cell recruitment to either modulate leukocyte recruitment to the injured tissue or enhance the targeted delivery of biologic therapeutics such as stem cells in an attempt to promote repair of the damaged heart.Keywords
Funding Information
- National Institutes of Health
- American Heart Association
- National Center for Advancing Translational Sciences
This publication has 124 references indexed in Scilit:
- Genomic responses in mouse models poorly mimic human inflammatory diseasesProceedings of the National Academy of Sciences, 2013
- Regulation of the Inflammatory Response in Cardiac RepairCirculation Research, 2012
- Rapid monocyte kinetics in acute myocardial infarction are sustained by extramedullary monocytopoiesisThe Journal of Experimental Medicine, 2012
- Therapeutic siRNA silencing in inflammatory monocytes in miceNature Biotechnology, 2011
- Differential regulation of human and murine P-selectin expression and function in vivoThe Journal of Experimental Medicine, 2010
- Angiotensin-Converting Enzyme Inhibition Prevents the Release of Monocytes From Their Splenic Reservoir in Mice With Myocardial InfarctionCirculation Research, 2010
- Impaired Infarct Healing in Atherosclerotic Mice With Ly-6ChiMonocytosisJournal of the American College of Cardiology, 2010
- Glycosylation in immune cell traffickingImmunological Reviews, 2009
- Systems‐level studies of glycosyltransferase gene expression and enzyme activity that are associated with the selectin binding function of human leukocytesThe FASEB Journal, 2008
- Initiation of Protein O Glycosylation by the Polypeptide GalNAcT-1 in Vascular Biology and Humoral ImmunityMolecular and Cellular Biology, 2007