FATTY ACID, CHOLESTEROL, AND ACETOACETATE BIOSYNTHESIS IN LIVER HOMOGENATES FROM NORMAL AND STARVED GUINEA PIGS
- 1 July 1960
- journal article
- Published by Canadian Science Publishing in Canadian Journal of Biochemistry and Physiology
- Vol. 38 (7), 635-641
- https://doi.org/10.1139/o60-078
Abstract
Fatty acid, cholesterol, and acetoacetate biosynthesis was studied with liver homogenates from normal and starved guinea pigs. Starvation suppressed the incorporation of acetate into fatty acids and cholesterol but not into acetoacetate. The in vitro biosynthesis of cholesterol and fatty acids was not restored by the addition of either G-6-P or isocitrate in combination with TPN, nor was it restored by orally dosing the starved animals with dextrose. The addition of isocitrate to normal homogenates depressed cholesterogenesis and stimulated lipogenesis.Keywords
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