PDF file 415K, Supplementary Figures 1-7. Figure S1, related to Figure 1. Genome-wide siRNA screen identifies determinants of resistance to erlotinib treatment. Figure S2, related to Figure 2. Reduced Nf1 expression in erlotinib-resistant EGFR-driven lung tumors. Figure S3, related to Figure 3. NF1 silencing confers resistance of lung adenocarcinoma cells to erlotinib. Figure S4, related to Figure 4. : NF1 downregulation activates MAPK pathway signaling. Figure S5, related to Figure 5. Low neurofibromin expressing cells respond to erlotinib when combined with MEK inhibition. Figure S6, related to Figure 6. Erlotinib-resistant murine EGFRL858R lung adenocarcinomas respond to combined EGFR and MEK inhibition. Figure S7, related to Figure 7. Reduced NF1 expression in erlotinib-resistant human NSCLC samples