Variation in Rate of Salicylate Elimination by Humans
- 1 August 1964
- Vol. 2 (5404), 286-288
- https://doi.org/10.1136/bmj.2.5404.286
Abstract
Salicylate-elimination rate, studied in a group of healthy adult men and women, varied appreciably between subjects. It is desirable that the dosage schedule in intensive salicylate therapy be adjusted individually on the basis of the patient''s predetermined salicylate elimination rate in order to prevent drug accumulation or gradual decline of drug concentration to subtherapeutic levels.Keywords
This publication has 7 references indexed in Scilit:
- Design of pharmacogenetic studies of drug metabolismJournal of Theoretical Biology, 1963
- Gastrointestinal Absorption of Aspirin AnhydrideJournal of Pharmaceutical Sciences, 1963
- PHARMACOGENETICSBritish Medical Bulletin, 1961
- Salicylate intoxication. Significance of measurements of salicylate in blood in cases of acute ingestion.1960
- Funktionale Beziehungen zwischen den pharmakokinetischen Eigenschaften und der Dosierung von ChemotherapeuticaKlinische Wochenschrift, 1960
- Metabolism of Drugs in Subjects with Laennec’s CirrhosisPharmacology, 1959
- Rapid determination of salicylate in biological fluidsBiochemical Journal, 1954