Convenient Preparation and Use of a New Analytical Construct for the Analysis and Development of Solid-Phase Chemistries
- 11 June 2003
- journal article
- Published by American Chemical Society (ACS) in The Journal of Organic Chemistry
- Vol. 68 (14), 5525-5533
- https://doi.org/10.1021/jo034340p
Abstract
An expedient and scalable synthesis of a versatile new analytical construct intermediate 1 is described. The utility of the intermediate 1 is exemplified by the preparation of the construct resin 14 incorporating an acid-labile linker which is used to conveniently develop optimized conditions leading to the preparation of a small compound array 24{1−3,1−3}. The optimized conditions are shown to work equally well on both the construct resin 14 and the corresponding base resin 15.Keywords
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