Adrenaline-Forming Enzyme in Brainstem: Elevation in Genetic and Experimental Hypertension
- 6 February 1976
- journal article
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 191 (4226), 483-484
- https://doi.org/10.1126/science.1246633
Abstract
The adrenaline-forming enzyme (phenylethanolamine N-methyltransferase) was elevated in the A1 and A2 regions of the brainstem of 4-week-old spontaneously (genetic) hypertensive rats and in the A1 region of adult experimentally (deoxycorticosterone acetate and sodium chloride) hypertensive rats. The administration of a phenylethanolamine N-methyltransferase inhibitor to experimentally hypertensive animals caused a reduction of the elevated blood pressure to normal values. These results implicate adrenaline-containing neurons in the brainstem in the development of hypertension.Keywords
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