Genetic Risk of Primary Open-angle Glaucoma

Abstract

THE CAUSE of primary open-angle glaucoma, in this article further referred to as glaucoma, is as yet unknown. This disorder is the second most prevalent cause of incurable blindness in the elderly.¹ Findings from epidemiological studies indicate that apart from high intraocular pressure^2,3 and age,⁴ ethnic origin,² diabetes mellitus,⁵ and familial history^6,7 are associated risk factors. Evidence for genetic factors has been found for juvenile-onset glaucoma^8-11 and for selected families with adult-onset glaucoma.^12-14