Adverse Effects of Methylmercury: Environmental Health Research Implications
Open Access
- 1 August 2010
- journal article
- review article
- Published by Environmental Health Perspectives in Environmental Health Perspectives
- Vol. 118 (8), 1137-1145
- https://doi.org/10.1289/ehp.0901757
Abstract
The scientific discoveries of health risks resulting from methylmercury exposure began in 1865 describing ataxia, dysarthria, constriction of visual fields, impaired hearing, and sensory disturbance as symptoms of fatal methylmercury poisoning.Our aim was to examine how knowledge and consensus on methylmercury toxicity have developed in order to identify problems of wider concern in research.We tracked key publications that reflected new insights into human methylmercury toxicity. From this evidence, we identified possible caveats of potential significance for environmental health research in general.At first, methylmercury research was impaired by inappropriate attention to narrow case definitions and uncertain chemical speciation. It also ignored the link between ecotoxicity and human toxicity. As a result, serious delays affected the recognition of methylmercury as a cause of serious human poisonings in Minamata, Japan. Developmental neurotoxicity was first reported in 1952, but despite accumulating evidence, the vulnerability of the developing nervous system was not taken into account in risk assessment internationally until approximately 50 years later. Imprecision in exposure assessment and other forms of uncertainty tended to cause an underestimation of methylmercury toxicity and repeatedly led to calls for more research rather than prevention.Coupled with legal and political rigidity that demanded convincing documentation before considering prevention and compensation, types of uncertainty that are common in environmental research delayed the scientific consensus and were used as an excuse for deferring corrective action. Symptoms of methylmercury toxicity, such as tunnel vision, forgetfulness, and lack of coordination, also seemed to affect environmental health research and its interpretation.Keywords
This publication has 64 references indexed in Scilit:
- Relation between Cord Blood Mercury Levels and Early Child Development in a World Trade Center CohortEnvironmental Health Perspectives, 2008
- Associations of maternal long-chain polyunsaturated fatty acids, methyl mercury, and infant development in the Seychelles Child Development Nutrition StudyNeuroToxicology, 2008
- Maternal Fish Intake during Pregnancy, Blood Mercury Levels, and Child Cognition at Age 3 Years in a US CohortAmerican Journal of Epidemiology, 2008
- Whole-ecosystem study shows rapid fish-mercury response to changes in mercury depositionProceedings of the National Academy of Sciences, 2007
- Separation of Risks and Benefits of Seafood IntakeEnvironmental Health Perspectives, 2007
- Delayed brainstem auditory evoked potential latencies in 14-year-old children exposed to methylmercuryThe Journal of Pediatrics, 2004
- Methylmercury Poisoning in Common Marmosets—MRI Findings and Peripheral Nerve LesionsToxicologic Pathology, 2002
- Deficits in Psychologic and Classroom Performance of Children with Elevated Dentine Lead LevelsNew England Journal of Medicine, 1979
- Mercury contamination: A human tragedyEnvironmental Management, 1978
- Ueber Quecksilberäthylverbindungen und über das Verhältniss der Quecksilberäthyl- zur QuecksilbervergiftungNaunyn-Schmiedebergs Archiv für experimentelle Pathologie und Pharmakologie, 1887