Melphalan‐Related Leukemia in Multiple Myeloma
- 12 January 1982
- journal article
- research article
- Published by Wiley in Acta Medica Scandinavica
- Vol. 211 (3), 203-208
- https://doi.org/10.1111/j.0954-6820.1982.tb01927.x
Abstract
Five patients with multiple myeloma ending in acute leukemia are described. The preleukemic phase was characterized by anemia, leukopenia and/or thrombocytopenia. The incidence of acute leukemia in myeloma was calculated to be 6%. Melphalan therapy for more than two years increased the incidence to 14%. All patients who developed leukemia had received a total melphalan dose of at least 1100 mg.Keywords
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