Complete Nucleotide Sequence of Two Multidrug-Resistant IncR Plasmids from Klebsiella pneumoniae
Open Access
- 1 July 2014
- journal article
- Published by American Society for Microbiology in Antimicrobial Agents and Chemotherapy
- Vol. 58 (7), 4207-4210
- https://doi.org/10.1128/aac.02773-13
Abstract
We report here the complete nucleotide sequence of two IncR replicons encoding multidrug resistance determinants, including β-lactam ( bla DHA-1 , bla SHV-12 ), aminoglycoside ( aphA1 , strA , strB ), and fluoroquinolone ( qnrB4 , aac6′-1b-cr ) resistance genes. The plasmids have backbones that are similar to each other, including the replication and stability systems, and contain a wide variety of transposable elements carrying known antibiotic resistance genes. This study confirms the increasing clinical importance of IncR replicons as resistance gene carriers.Keywords
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