SOME EFFECTS OF FRESH PITUITARY HOMO-IMPLANTS AND OF THE GONAD-STIMULATING SUBSTANCE FROM HUMAN PREGNANCY URINE ON THE REPRODUCTIVE TRACT OF THE MALE RAT

Abstract

Fresh hypo-physeal implants in 4 immature [male] rats and injections of urinary hebin[long dash]the gonad-stimulating substance from human pregnancy urine (Wallen-Lawrence and Van Dyke) [long dash]in 14 immature [male] rats, produced (a) slight increases in gross measurements of the testis; little or no increase in tubular diameter; little, if any, acceleration of spermatogenesis; and decided increase in the interstitial tissue; (b) decided increases in the size of the prostate gland and seminal vesicles; (c) marked precocious attainment of secretory differentiation in the seminal vesicles. Urinary hebin injections produced in 10 normal adult [male] rats a marked increase in the size of the prostate glands and seminal vesicles; secretion granules were both more numerous and larger. Visible effects on the testis were limited to slight increase in interstitial tissue. Injections of urinary hebin into castrated [male][male] were without effect upon the reproductive tract.