Hybrid-Designed Inhibitors of p38 MAP Kinase UtilizingN-Arylpyridazinones

Abstract
Imidazo[1,2-a]pyridyl N-arylpyridazinones were hybridized from the classic pyridinylimidazoles and the more recent dual hydrogen bond acceptors, resulting in a new structural class of selective p38 MAP kinase inhibitors.