THE RELATIONSHIP OF KIDNEY FUNCTION TO THE GLUCOSE UTILIZATION OF THE EXTRA ABDOMINAL TISSUES

Abstract

Evidence is presented to prove that eviscerated animals, and fasted hepatectomized animals are excellent preps. for the quantitative study of the rate of sugar utilization in the remaining tissues of the body. The physiological processes of the animal[long dash]other than those directly connected with the organ removed[long dash]must be normal if one is to make this assumption. Removal of the kidneys or stoppage of the function in such prepns. leads to a marked increase in their glucose requirement. Deductions made in the past as to the sugar utilization rate of the tissues of normal and of diabetic animals which are based on observations on hepatectomized animals without kidney function, must be considered in the light of these findings.