Differential expression of CD25 and HC2 antigens on subtypes of acute myeloid leukemias
- 1 May 1989
- journal article
- research article
- Published by Wiley in European Journal of Haematology
- Vol. 42 (5), 436-440
- https://doi.org/10.1111/j.1600-0609.1989.tb01467.x
Abstract
The presence of CD25 and HC2 antigens in 66 different patients with acute myeloid leukemia (AML) was investigated. The expression of both antigens was observed in 32% of AML cells. Dual fluorescence staining experiments performed in 5 AML patient cells showed that CD25 and HC2 antigens were simultaneously expressed in a single cell. The expression of both antigens was mainly observed in the M4 and M5 subtypes of AML. Although immunopurified IL-2 was able to block the binding of anti-CD25 monoclonal antibody to the AML cells, the IL-2 receptor did not appear to be functional.Keywords
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