CARRIER FUNCTION IN ANTI-HAPTEN ANTIBODY RESPONSES
Open Access
- 1 July 1971
- journal article
- Published by Rockefeller University Press in The Journal of Experimental Medicine
- Vol. 134 (1), 201-223
- https://doi.org/10.1084/jem.134.1.201
Abstract
Administration of nonimmunogenic 2,4-dinitrophenyl (DNP) conjugates of copolymers of D or L-glutamic acid and lysine (GL) induces hapten-specific tolerance in nonimmune and DNP-ovalbumin-primed strain 13 guinea pigs. This tolerant state is evidenced by depressed anti-DNP antibody synthesis in response to challenge with DNP-ovalbumin and by a diminished frequency of DNP-specific antigen-binding cells and of anti-DNP antibody-secreting cells.Keywords
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