Antihyperglycaemic effect and acute toxicity of Securigera Securidaca L. seed extracts in mice
- 28 November 2002
- journal article
- Published by Wiley in Phytotherapy Research
- Vol. 16 (8), 745-747
- https://doi.org/10.1002/ptr.1020
Abstract
The antihyperglycaemic activity of a Securigera securidaca aqueous infusion and an ethanol maceration extract of seeds was studied in normoglycaemic, glucose‐induced hyperglycaemic and alloxan‐induced diabetic mice. The acute toxicity of the ethanol extract was more than that of the aqueous one. The phytochemical analysis showed that the seed extracts were rich in flavonoids. The intraperitoneal and oral administration of the aqueous and ethanol extracts significantly reduced blood glucose in alloxan‐induced diabetic mice. In normoglycaemic and glucose‐induced hyperglycaemic mice, the blood glucose levels were not significantly different from the control. Glibenclamide was not able to lower blood glucose in alloxan‐induced diabetic mice, while it significantly lowered the blood sugar in normoglycaemic mice. The results indicate that S. securidaca seed extracts significantly reduce blood glucose in alloxan‐induced diabetic mice by a mechanism different from that of sulfonylurea agents. Copyright © 2002 John Wiley & Sons, Ltd.Keywords
This publication has 5 references indexed in Scilit:
- Natural products with hypoglycemic, hypotensive, hypocholesterolemic, antiatherosclerotic and antithrombotic activitiesLife Sciences, 1999
- MetforminNew England Journal of Medicine, 1996
- Hypoglycemic activity of Salvia fruticosa Mill. from CyprusJournal of Ethnopharmacology, 1991
- Oral Hypoglycemic AgentsNew England Journal of Medicine, 1989
- Effect of Securigera Securidaca on Electroshock Seizure Threshold in MicePsychological Reports, 1969