Importance of L3T4+ and Lyt-2+ cells in the immunologic control of infection with Mycobacterium bovis strain bacillus Calmette-Guérin in mice. Assessment by elimination of T cell subsets in vivo.
- 15 September 1987
- journal article
- research article
- Published by The American Association of Immunologists in The Journal of Immunology
- Vol. 139 (6), 2032-2037
- https://doi.org/10.4049/jimmunol.139.6.2032
Abstract
The course of infection after injection of small doses of bacillus Calmette-Guérin (BCG) was studied in mice which were depleted in vivo of T cell subsets by administration of either anti-L3T4 or anti-Lyt-2 mAb. The results presented herein strongly suggest that the L3T4+ subpopulation play a pivotal role in the immunologic control of BCG infection because the depletion of L3T4+ cells led to a dramatic increase in the number of viable bacteria. Depletion of Lyt-2+ cells had no significant effect on the course of infection. These results were confirmed by using adoptive transfer experiments which showed that protective immunity was mediated by L3T4+ cells generated in the spleen as a result of infection. Moreover, T cells capable of controlling the recurrence of BCG multiplication from residual bacteria remaining in organs after the recovery from infection were shown to belong to the L3T4+ subpopulation.This publication has 13 references indexed in Scilit:
- Therapeutic effect of anti-L3T4 monoclonal antibody GK1.5 on cutaneous leishmaniasis in genetically-susceptible BALB/c mice.The Journal of Immunology, 1985
- I-A RESTRICTED ACTIVATION BY T-CELL LINES OF ANTI-TUBERCULOSIS ACTIVITY IN MURINE MACROPHAGES1985
- Adoptive protection of the Mycobacterium tuberculosis-infected lungCellular Immunology, 1984
- DEMONSTRATION OF ACQUIRED-RESISTANCE IN BCGR INBRED MOUSE STRAINS INFECTED WITH A LOW-DOSE OF BCG MONTREAL1984
- Protection against Mycobacterium tuberculosis infection by adoptive immunotherapy. Requirement for T cell-deficient recipients.The Journal of Experimental Medicine, 1983
- CHARACTERIZATION OF THE MURINE T-CELL SURFACE-MOLECULE, DESIGNATED L3T4, IDENTIFIED BY MONOCLONAL-ANTIBODY GK1.5 - SIMILARITY OF L3T4 TO THE HUMAN LEU-3-T4 MOLECULE1983
- Immunopathology of BCG infection in genetically resistant and susceptible mouse strains.The Journal of Immunology, 1982
- Genetic control of natural resistance to Mycobacterium bovis (BCG) in mice.The Journal of Immunology, 1981
- IgG or IgM monoclonal antibodies reactive with different determinants on the molecular complex bearing Lyt 2 antigen block T cell-mediated cytolysis in the absence of complement.The Journal of Immunology, 1980
- Specific Lyt 123 cells are involved in protection against Listeria monocytogenes and in delayed-type hypersensitivity to listerial antigens.The Journal of Experimental Medicine, 1979