A primary screen for drugs to prevent transmission of Chagas's disease during blood transfusion
- 1 January 1982
- journal article
- Published by Oxford University Press (OUP) in Transactions of the Royal Society of Tropical Medicine and Hygiene
- Vol. 76 (5), 633-635
- https://doi.org/10.1016/0035-9203(82)90228-0
Abstract
This paper describes how Microslide tubes can be used as the basis for a quick, simple, inexpensive screen to test for compounds which might prevent the transmission of Chagas's disease as a result of blood transfusion. The test uses Trypanosoma cruzi-infected mouse blood and requires only very small amounts of compound. The screen identifies compounds known to be active against blood trypomastigotes in vitro at 4 °C, and is apparently free of false negative and positive results.Keywords
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