Transfusion‐associated noncardiogenic pulmonary edema
- 6 May 1986
- journal article
- research article
- Published by Wiley in Transfusion
- Vol. 26 (3), 278-281
- https://doi.org/10.1046/j.1537-2995.1986.26386209388.x
Abstract
Although noncardiogenic pulmonary edema (NCPE) is a recognized complication of blood transfusion, the precise etiology is not well understood. NCPE may be secondary to complement-mediated pulmonary capillary injury initiated by either donor or recipient anti-leukocyte antibodies. It is not caused by simple volume overload. Recent blood banking texts and published case reports continue to suggest diuretics as part of the initial therapy for this complication. we report a case of transfusion-associated NCPE in which empirical diuretic therapy clearly was detrimental and suggest that the use of diuretics for treatment of this condition is not warranted. Reversal of progressive hypoxemia is the mainstay of therapy. Hemodynamic monitoring is important in differentiating NCPE from pulmonary edema secondary to cardiac failure or volume overload and should be used as a guide for further therapy.This publication has 7 references indexed in Scilit:
- Transfusion-related Acute Lung Injury Associated with Passive Transfer of Antileukocyte Antibodies1,2American Review of Respiratory Disease, 1983
- Fulminating noncardiogenic pulmonary edemaThe Journal of Thoracic and Cardiovascular Surgery, 1980
- Complement-Induced Granulocyte AggregationNew England Journal of Medicine, 1980
- Fatal Pulmonary Hypersensitivity Reaction to HL‐A Incompatible Blood Transfusion:Transfusion, 1976
- Severe Allergic Pulmonary Oedema after Plasma TransfusionBritish Journal of Haematology, 1972
- Pulmonary Infiltrates Associated with Leukoagglutinin Transfusion ReactionsAnnals of Internal Medicine, 1970
- Pulmonary hypersensitivity reaction after blood transfusionArchives of Internal Medicine, 1968