Enantioselective Total Synthesis of the Selective PI3 Kinase Inhibitor Liphagal
- 2 June 2010
- journal article
- letter
- Published by American Chemical Society (ACS) in Organic Letters
- Vol. 12 (20), 4450-4453
- https://doi.org/10.1021/ol101173w
Abstract
The enantioselective total synthesis of liphagal, a selective inhibitor of PI3K α isolated from the marine sponge Aka coralliphaga, has been achieved. The novel tetracyclic “liphagane” skeleton is formed in one step, after the hydrogenation of a dihydroxydrimane phenol benzyl ether in the presence of cationic resin.Keywords
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