A novel strategy for bioconjugation: synthesis and preliminary evaluation with amphotericin B
- 1 January 2006
- journal article
- research article
- Published by Royal Society of Chemistry (RSC) in Organic & Biomolecular Chemistry
- Vol. 5 (9), 1339-1342
- https://doi.org/10.1039/b701953j
Abstract
A novel linker strategy is presented based on a double reductive amination of a dialdehyde to the amine of the amphotericin B mycosamine sugar and the biological activity of a series of conjugates is compared to the native amphotericin B.Keywords
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