Immunoreactive dUMP and TTP pools as an index of thymidylate synthase inhibition; effect of tomudex (ZD1694) and a nonpolyglutamated quinazoline antifolate (CB30900) in L1210 mouse leukaemia cells
- 1 May 1996
- journal article
- Published by Elsevier BV in Biochemical Pharmacology
- Vol. 51 (10), 1293-1301
- https://doi.org/10.1016/0006-2952(96)00035-4
Abstract
No abstract availableKeywords
This publication has 27 references indexed in Scilit:
- 701 ‘Tomudex’ (ZD1694) has a higher response rate, significantly less leucopenia and mucositis and a simpler dosing regimen than 5-fluorouracil (5-FU) and leucovorin (LV) for advanced colorectal cancer (CRC): First results of a phase III studyEuropean Journal Of Cancer, 1995
- Folate-based thymidylate synthase inhibitors as anticancer drugsAnnals Of Oncology, 1995
- Mechanisms of acquired resistance to the quinazoline thymidylate synthase inhibitor ZD1694 (Tomudex) in one mouse and three human cell linesBritish Journal of Cancer, 1995
- Biochemical effects of folate-based inhibitors of thymidylate synthase in MGH-U1 cellsCancer Chemotherapy and Pharmacology, 1994
- The in vivo metabolic stability of dipeptide analogues of the quinazoline antifolate, ICI 198583, in miceBiochemical Pharmacology, 1993
- Enhancement of thymidylate synthase inhibitionCurrent Opinion in Oncology, 1993
- The biochemical pharmacology of the thymidylate synthase inhibitor, 2-desamino-2-methyl-N10-propargyl-5,8-dideazafolic acid (ICI 198583)Biochemical Pharmacology, 1991
- Modulation of anti-metabolite effectsBiochemical Pharmacology, 1984
- Biochemical effects of a quinazoline inhibitor of thymidylate synthetase, N-(4-(N-((2-amino-4-hydroxy-6-quinazolinyl)methyl)prop-2-ynylamino)benzoyl)-l-glutamic acid (CB3717), on human lymphoblastoid cellsBiochemical Pharmacology, 1983
- Factors determining cell sensitivity to methotrexate: Studies of folate and deoxyribonucleoside triphosphate pools in five mammalian cell linesEuropean Journal of Cancer (1965), 1974