EFFECT OF DIABETES AND INSULIN ON THE ACTIVITY OF MYOCARDIAL AND ADIPOSE TISSUE LIPOPROTEIN LIPASE OF RATS*

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Abstract
The lipoprotein lipase (LPL) activity of myocardial and epididymal fat tissue of normal, diabetic, and insulin-treated diabetic rats was compared. In normal rats the LPL activity of adipose tissue was considerably higher than the activity of the myocardium. Diabetes produced a decrease in the LPL activity of adipose tissue and a marked elevation of the myocardial LPL activity. Administration of insulin to the diabetic animals restored the LPL activity of both tissues to normal. The possibility that changes of the enzymatic activity in the tissues, produced by carbohydrate deficit, may represent a mechanism for diverting energy-rich fatty acids from the depots to the heart is discussed.