Gestational trophoblastic neoplasia with retroperitoneal metastases: A fatal complication
Open Access
- 30 December 2010
- journal article
- case report
- Published by Springer Science and Business Media LLC in World Journal of Surgical Oncology
- Vol. 8 (1), 114
- https://doi.org/10.1186/1477-7819-8-114
Abstract
Background Gestational Trophoblastic Neoplasia (GTN) is a pathologic entity that can affect any pregnancy and develop long after the termination of the pregnancy. Its course can be complicated by metastases to distant sites such as the lung, brain, liver, kidney and vagina. The therapeutic approach of this condition includes both surgical intervention and chemotherapy. The prognosis depends on many prognostic factors that determine the stage of the disease. Case Report We present a woman with GTN and retroperitoneal metastatic disease who came to our department and was diagnosed as having high risk metastatic GTN. Accordingly she received chemotherapy as primary treatment but unfortunately developed massive bleeding after the first course of chemotherapy, was operated in an attempt to control bleeding but finally succumbed. Conclusion This case demonstrates that GTN, while usually curable, can be a deadly disease requiring improved diagnostic, treatment modalities and chemotherapeutic agents. The gynaecologist should be aware of all possible metastatic sites of GTN and the patient immediately referred to a specialist center for further assessment and treatment.Keywords
This publication has 27 references indexed in Scilit:
- Gestational trophoblastic disease II: classification and management of gestational trophoblastic neoplasiaAmerican Journal of Obstetrics and Gynecology, 2010
- Placental site trophoblastic tumor: report of four cases and review of literatureInternational Journal of Gynecologic Cancer, 2007
- Occult choriocarcinoma discovered by positron emission tomography/computed tomography imaging following a successful pregnancyGynecologic Oncology, 2005
- Secondary chemotherapy for high-risk gestational trophoblastic neoplasiaGynecologic Oncology, 2005
- Persistent gestational trophoblastic disease is rarely, if ever, derived from non-molar first-trimester miscarriageMedical Hypotheses, 2005
- Diagnosis and treatment of gestational trophoblastic disease: ACOG Practice Bulletin No. 531Gynecologic Oncology, 2004
- Clinical Outcome of Micrometastasis in the Lung in Stage IA Persistent Gestational Trophoblastic DiseaseGynecologic Oncology, 1998
- Presentation and management of choriocarcinoma after nonmolar pregnancyBJOG: An International Journal of Obstetrics and Gynaecology, 1995
- Intraoperative Radiation Therapy in Gynecologic Cancer: The Mayo Clinic ExperienceGynecologic Oncology, 1993
- Gestational trophoblastic tumours following initial diagnosis of partial hydatidiform moleThe Lancet, 1990